Hitting the mother lode of tumor angiogenesis

From mother duck to mother lode: clinical education for deep learning.

this lovely mixed metaphor had its origins in a recent presentation by Vicky Niederhauser (2009), who described the need to shift from the longstanding “mother duck” model of clinical education and humorously portrayed the great risks to the “baby-duckling” nursing students as their mother-duck faculty member attempts to lead them through a clinical day. and the “mother lode?” that refers to th...

Tumour angiogenesis: Hitting cancer where it hurts

Tumorigenesis is a complex and multi-factorial process. In the first instance, it requires the accumulation of a series of genetic mutations within preneoplastic cells which uncouple the cells’ normally highly interdependent programmes of growth and differentiation. But oncogenic mutations cannot liberate the expanding tumour population from the need to supply itself with nutrients and oxygen, ...

Coronary sinus in the management of functional mitral regurgitation: the mother lode or fool's gold?

The past 5 years have seen the introduction into the preclinical arena of myriad devices for the potential treatment of functional and ischemic mitral regurgitation by a percutaneous approach.1 A number of the device concepts have taken advantage of the relatively easy access to the posterior annulus of the mitral valve provided by the coronary sinus. Although attractive on initial consideratio...

The mother lode of liver transplantation, with particular reference to our new journal.

angiogenesis and tumor

angiogenesis, the process of new blood vessel formation from existing ones, plays an important role in  the physiologic circumstances such as embryonic development, placenta formation, and wound healing. it is also crucial to progress of pathogenic processes of a variety of disorders, including tumor growth and metastasis. in general, angiogenesis process is a multi-factorial and highly structu...